The Biology of Cancer & Chemical Carcinogenesis

• Environmental Cancer Risks

Basic concepts in cancer biology

1. Common cancer misconceptions
1. Cancer trends
• Cancer Death Rates
• Question and Answers about trends in cancer mortality
• Cancer Trends
• Trends in Brain Tumors
2. Human carcinogens
• Substances known to be human carcinogens
• Five most commonly diagnosed cancers amoung females
• A list of know carcinogens
• Known Human Carcinogens
• Carcinogens
• 8th Report on Carcinogens
• Chemical causes of Cancer
• Carcinogenesis
2. Cancer cell biology
1. Benign vs. malignant tumors
• Comparison Between benign and malignant tumors
2. Stages in tumor growth
• Stages of tumor growth and mestastisis
3. Characteristics of malignant cells
3. The Neoplastic Process
• Neoplastic disease
• Neoplasia II: Metastasis self Assessment Quiz
• Consequences of neoplasia induced bone resorption and the use of clodronate
• What is a Tumor Promoter?
• More about cancer
• Neoplasia
1. Initiation
2. Promotion
3. Progression

Mutation of DNA

• Introduction to DNA structure
• Structure of DNA
• Cell to Gene Progression
• Mutation, Mutagens, and DNA Repair
• Information on UV DNA damage.
• DNA Vocabulary
• DNA Mutations
• Mutation
• Mutation
• Gene Mutation
1. Transition
2. Transversion
3. Frameshift

Chromosomal Abnormalities

1. Translocations
2. Single strand breaks - clastogenic agents
• Alzheimer's disease
• Alzheimer's disease, molecular genetics of
• Dementia with Lewy bodies

Polyploidy and Aneuploidy

1. Trisomy 21
2. Down's Syndrome
• Definition of Down's syndrome
• Down's Syndrome Title Page
• Down's Syndrome
• Down's Syndrome

Repair of DNA damage

• DNA Repair (Magazine) Online
• Mutagenesis and DNA Repair
• Radiation Damage and DNA Repair
• DNA Damage and Repair I
• DNA Repair
• Repair Mechanisms of Radiation-Induced DNA Damage
• Monitoring Populations for DNA Repair Deficiency and for Cancer susceptibility
• DNA Repair Keywords
• DNA Repair
1. Thymine dimers
• Definition of thymine
• Thymine component index
• Thymine
• Thymine - Movable diagram
• Dihydro-thymine - Another interactive thymine molecule and description.
• Electron Transfer between Photolyase and DNA Thymine Dimer
2. Repair deficient mutants

Screening of DNA modifying agents

1. Ames assay
• The Ames test

Chemical Modification of Nucleotides

1. Common alkylating agents, base analogs
2. Example of 2-AAF metabolism
1. Insertion into the minor groove
2. Insertion into the helix
3. Metabolic enzyme polymorphisms