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Factors that Potentially Affect the Toxicity of a Chemical

  • Dose
  • Duration of exposure
  • Biological activity of the toxicant (inherent toxicity)
  • Route of exposure
  • Age of animal
  • Sex of the animal
  • Genetic composition (pre-disposition)
  • Overall health at the time of exposure
  • Other factors (i.e. chemical interactions, nutritional status)