FIFRA, Pesticide Registration & Re-registration

• 1906 - Federal Food & Drug Act
• 1938 - Federal Food, Drug, & Cosmetic Act
• 1954, 1958 - Amendments to Food, Drug & Cosmetic Act
• Established tolerances
• Delaney Clause - "No additive shall be deemed safe if it is found to induce cancer when it is ingested by man or animal or, if it is found, after tests which are appropriate for evaluation of the safety of food additives, to induce cancer in man or animals."
• 1947 - Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA)
• Labelling statute under USDA
• 1959, 1961 - FIFRA Amendments
• registration
• 1972 - FIFRA reorganized under EPA jurisdiction
• 1975, 1978, 1980, 1984 - FIFRA Amendments
• Review and re-registration
• Chemical, environmental impact, toxicology, tolerance on residues, monitoring (still FDA), use restriction
• Estimated date of completion: 2024, 2 re-registered
• Cost of development: 30-50 million each, ~17 years

(Amdur, Mary O., John Doull, and Curtis D. Klaassen. Toxicology, 1991, p. 569)

(Amdur, Mary O., John Doull, and Curtis D. Klaassen. Toxicology, 1991, p. 569)