Oncogenes & Tumor Suppressor Genes,
Genetic Predisposition to Cancer

Oncogenes & Tumor Suppressor Genes

• Latent Viruses and Mutated Oncogenes: No Evidence for Pathogenicity
• Cancer Genetics - Includes sections on Oncogenes & Tumor Suppressor Genes
• Lecture 28: Cancer II - Outline of oncogenes, etc.
• Cardiac hypertrophy - includes section of oncogenes.
• Lecture 18 - Contains information on oncogenes as well as tumor suppressor genes and their effect on cancer.
• Molecular roots of cancer: Grzegorz Nalepa explains what happens when a cell starts to rebel - Normal cells v cancer cells: the good, the bad, and the ugly.
• Cancer - with an extensive section on Oncogenes and tumor suppressor genes.
• Oncogenes and Cancer
• Molecular Basis of Neoplasia - with section on Oncogenes and cancer.
• Oncogenes
• Cancer II: Oncogenes
• What are Genes? Oncogenes? Proto-oncogenes?
• Viruses and cancer
• Mechanisms of Carcinogenesis
• The Promise of Cancer genetics - Contains information both Tumor suppressor genes as well as oncogenes.
• Gene Regulation and cancer
• Oncogenes - PowerPoint presentation
1. Definition of oncogenes, proto-oncogenes, and tumor suppressor genes
2. Viral oncogenes
• Tumor viruses - includes section on Oncogenetic Tumor viruses
• Discovering viral oncogenes
• Viral oncogene quiz
• Why all the chickens? - Oncogenes and testing with chickens
3. Cellular Proto-oncogenes
• Discovering oncogenes: Cellular
• Proto-Oncogenes and Cancer
• Oncogenes and Proto-Oncogenes
• Oncogenes - their protein products and functions.
4. Activation of oncogenes
• Mode d'activation des oncogenes - Excellent web-site (in French)
1. Via gene amplification
• DNA copy number amplifications in human neoplasms
2. Via chromosomal translocation
5. Oncoproteins and their activities
1. Phosphorylation of tyrosine
2. G-proteins
3. Transcription factors
4. Growth factors
5. Role in cell cycle "cyclins" regulation
6. p53 and tumor suppressor genes
• Tumor suppressor genes
• Tumor suppressor genes
• Genes and diseases - the p53 gene
• Cancer overview and tumor suppressor genes
• Structure and function of the p53 tumor suppressor gene
• Tumor suppressor genes and the AIDS Virus
• What is a tumor suppressor gene?
• Tumor suppressors and cancer
• p53 is a tumor suppressor
• Is p53 an oncogene or a tumor suppressor?
1. Frequency of mutation in cancer
2. Role in cell cycle
3. Activation of Waf-1 and p21
4. Mutational spectrum
5. Loss of heterozygosity (LOH)

Genetic Predisposition to Cancer

• Genetic predisposition to cancer
• Genetic predisposition to cancer - an overview
• Hereditary Breast and/or Ovarian Cancer Predisposition
• Cancer Genetics
1. N-Acetylation polymorphism
• N-Acetyltransferase Polymorphisms and Colorectal Cancer
1. Autosomal dominant genetics
2. Drug acetylation differences discovered in 1960
3. Risk of bladder, lung, and liver cancer
2. Dibrisoquin P450 polymorphism
1. Risk of lung cancer