Target Organ Toxicity

Basic concepts in tissue sensitivity

• DNA repair - Correction of damaged cell structures.

The Liver

• The Liver
• The Healthy Liver - Excellent detail. Describes the many functions of the liver.
• The Liver: Introduction and Index
• Hepatic Pathology Index
• Liver Support Systems - Detailed descriptions of the liver's function and failure.
• The kidney and adrenal gland and the liver - Note: both are included. Scroll down the page for the liver.
• Structure and physiology of the Liver
• Textbook on Liber Pathology
• Digestive System - Good section on the liver, also contains information on the rest of the digestive system.
• Diagram of the Liver
• Liver: Central Vein and Hepatocites
• Structure and Function of the Liver
• Digestive Glands - Scroll down to "Liver" about 1/4 of the way down
• Images of the liver, etc.
• Liver and Gall Bladder
• Liver Diagram
• The Liver and Pancreas - Normal Structure and Function of the Liver
1. The liver lobule, hepatocytes, Kupffer cells, sinusoids
• Liver Lobule
2. The hepatic triad
• Diagram of the Hepatic triad
• Light micrograph of triad
• Liver: Hepatic Triad Picture
• Digestive system: Hepatic Triad
3. Role of the hepatocyte
1. Produce bile
• Bile - What is bile?
• Secretion of Bile and the Role of Bile Acids in Digestion
• Bile
• Bile Acids Synthesis and Utilization
• Bile overview
• Bile Produced in the liver - diagram
• Bile
2. Absorb nutrients
3. Store fat soluble vitamins
4. Detoxify xenobiotics and metabolic waste
4. Classification of liver injury

The Kidney

• Renal pathology
• The Parts and Workings of the Human Kidney
• Excretion - Human body and excretion--brief overview.
• The kidney and adrenal gland and the liver - Note: both are included.
• Urinary System - Quizes and diagrams.
• Basic Principles of Renal Physiology
• Renal Physiology and Disease
• Images of the Kidney, etc.
1. Basic renal physiology
• Basic Concepts in Renal Physiology
• American Journal of Renal Physiology
• How the Kidney Works
• Renal Pathophysiology
• Renal Physiology
2. The Nephron, Glomerulus, & Bowman's Capsule
• Nephron Test - do you know your Nephron? Test yourself.
• Nephron Test 2
• Nephron Test 3
3. Nephrotoxicants (heavy metals - Hg & Cd)
• Kidneys and Metals Problem Set - metals and their effects on the Kidney.

The Skin

• The Skin
• Environmental Health and the skin - the problems associated from contact with chemicals.
• Dermatitis Escezma - Skin diseases associated with toxins.
• Toxic shock syndrome - causes and effects.
• National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health
• Skin Conditions
1. Anatomy and Metabolic Capacity
• Map of the skin
• Anatomy of the Skin
• Brief: Anatomy of the Skin
• Anatomy of the skin
• Skin
2. Chemicals affecting absorption through skin
3. Occupational dermatitis
• Occupational Dermatitis
• Occupational Dermatitis
4. Chemical exposures leading to skin irritation or pathology
• Chemical peel - how chemicals can cause skin burn.
• Cutaneous Toxicity - pesticides, etc. and their effect on the skin.
• List of toxic wood - Wood that irritates the skin.
1. Chemical allergy - sensitizing agents
2. Phototoxicity and sensitization
3. Chemical burns - acids & bases
• Chemical Burns
• Poison on the Skin and Chemical Burns
4. Chemical acne - chloracne
• Chloracne
• Occupational Acne
• Chloracne Brief
• Chloracne
5. Dermal absorption of systemic toxicants
5. Skin cancer
• An Introduction to Skin Cancer
• What You need to Know about Skin Cancer
• National Skin Cancer Foundation

The Immune System

• Understanding the Immune System
• Cells and Organs of the Immune system
• Organs of the Immune system
• Lots of Pictures, diagrams, etc.
• What is Immunity?
• Immunology and the Immune system
• Immune System Lecture Outline
1. Non-specific immune factors
2. Antigens and antibodies
• Antibodies and antigens
• Antigens, Antibodies, and the TCR
3. Division of the Immune Effector Cells
1. B cells, T cells, and APCs
• Plasma Cell World -- Dedicated to B cells.
2. T helper cells and Cytotoxic T cells
• T Helper Cells
• Helper T Cells (Keep clicking on the right arrow)
4. Antibody-Based Immunity
1. Antibody structure and function
2. Antibody-mediated cell killing
5. Cell-Mediated Immunity
1. T cell diversity, MHC restriction
2. Cytotoxic T cells and perferin

Lung Toxicology Problem Set and Tutorial